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Recombinant SMMHC Antibody

CAT: 0013-GTR18082036-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082036-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Smooth muscle myosin heavy chain (SM-MHC) is a cytoplasmic structural protein, which is a major component of the contractile apparatus in smooth muscle cells. Expression of smooth muscle myosin is developmentally regulated, appearing early in smooth muscle development, and is specific for smooth muscle development. Two isoforms of smooth muscle myosin heavy chain have been identified, designated MHC-1 and MHC-2. The antibody may be useful for the study of breast tumors as the presence of an intact layer of myoepithelial cells is an important feature, which may distinguish benign breast lesions and carcinoma in situ from invasive tumors.
UniProt
P35749
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for the recombinant SMMHC antibody.
Clonality
Recombinant
Clone
MYH11/2303R
Conjugation
Unconjugated
Field of Research
Musculoskeletal & Connective Tissue Research
Purification
Protein A affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant SMMHC antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Rabbit
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Rabbit IgG, kappa

UniProtKB · P35749

Myosin-11

MYH11_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35749
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MYH11
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
D2JYH7, O00396, O94944, P78422, Q3MIV8, Q3MNF0, Q3MNF1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Actin-bindingCalmodulin-bindingMotor proteinMuscle proteinMyosin

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Disease

Aortic aneurysmDisease variantProto-oncogene

Ligand

ATP-bindingNucleotide-binding

Domain

Coiled coil

PTM

MethylationPhosphoprotein

Cellular component

Thick filament

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