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Recombinant Bcl2 Antibody

CAT: 0013-GTR18081882-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18081882-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Expression of Bcl-2 alpha oncoprotein inhibits the programmed cell death (apoptosis) . In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies.
UniProt
P10415
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the recombinant Bcl2 antibody.
Clonality
Recombinant
Clone
RBCL2/782
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Protein G affinity chromatography
Dilution
Flow cytometry: 1-2ug/10^6 cells, Immunofluorescence: 1-2ug/ml, Western blot: 1-2ug/ml, Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant Bcl2 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
FACS, IF, IHC-P, WB
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1, kappa

UniProtKB · P10415

Apoptosis regulator Bcl-2

BCL2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P10415
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BCL2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
C9JHD5, P10416, Q13842, Q16197
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

ApoptosisAutophagy

Cellular component

CytoplasmEndoplasmic reticulumMembraneMitochondrionMitochondrion outer membraneNucleus

Disease

Disease variantProto-oncogene

PTM

PhosphoproteinUbl conjugation

Domain

TransmembraneTransmembrane helix

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