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Scribble (phospho-Ser1220) rabbit pAb

CAT: 0855-ES13179-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES13179-01Size:50 µL
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Background
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Description
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
UniProt
Q14160
Swiss Prot
Q14160
Reactivity
Human; Mouse
Immunogen
Synthesized phosho peptide around human Scribble (Ser1220)
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Molecular Weight
179kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
179kD
Fragment
IgG
Subcellular Location
Cell membrane ; Peripheral membrane protein. Cell junction . Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse . Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (By similarity) . .
Other Product Names
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene ID (Human)
23513

UniProtKB · Q14160

Protein scribble homolog

SCRIB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14160
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SCRIB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Scribble, hScrib
EC number
—
Processing
—
Secondary accessions
Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneCell projectionCytoplasmMembraneSynapse

Domain

Coiled coilLeucine-rich repeatRepeat

Molecular function

Developmental protein

Biological process

Differentiation

Disease

Disease variant

PTM

LipoproteinPalmitatePhosphoproteinUbl conjugation

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