Parathyroid Hormone Antibody

CAT: 0013-GTR18081493-01Size: 20 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18081493-01Size:20 µg

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Description

Epitope of this mAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH) ; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

UniProt

P01270

Reactivity

Human

Immunogen

A synthetic peptide corresponding to amino acids 1-34 of human PTH was used as the immunogen for the Parathyroid Hormone antibody.

Clonality

Monoclonal

Clone

PTH/911

Conjugation

Unconjugated

Field of Research

Metabolism Research

Purification

Protein G affinity chromatography

Dilution

Immunohistochemistry (FFPE) : 0.5-1ug/ml for 30 min at RT

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the Parathyroid Hormone antibody should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Tested Applications

IHC-P

Host or Source

Mouse

Preservative

0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide

Isotype

Mouse IgG2b, kappa

UniProtKB · P01270

Parathyroid hormone

PTHY_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P01270
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PTH
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: PTH
EC number: —
Processing: Precursor
Secondary accessions: Q4VB48, Q9UD38

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Cleavage on pair of basic residues

Disease

Disease variant

Molecular function

Hormone

Cellular component

Secreted

Domain

Signal

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Alternative Products

Catalog	Name
GWB-T00256	Parathyroid Hormone Antibody