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PBP10

CAT: 0804-HY-P1116-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1116-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1[1]. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects[2].
CAS Number
794466-43-6
UNSPSC
12352209
Target
Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pbp10.html
Purity
98.13
Solubility
10 mM in DMSO
Smiles
N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CCC(N)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC(C2=C(C=CC=C2)C3=C(C=CC(N(CC)CC)=C4)C4=[O+]C5=C3C=CC(N(CC)CC)=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C84H127N24O15
Molecular Weight
1713.06
References & Citations
[1]Ewelina Piktel, et al. Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin. J Nanobiotechnology. 2019 Feb 2;17 (1) :22.|[2]C C Cunningham, et al.Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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