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CYLD Antibody

CAT: 0013-GTR18080841-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18080841-01Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.
Reactivity
Human, Mouse
Immunogen
A recombinant protein fragment from the N-termiinal region of human CYLD was used as the immunogen for this antibody.
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Neuroscience
Purification
Protein A affinity chromatography
Dilution
Western blot: 2-5ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Provided assay concentrations are suggestions only, CYLD antibody titration may be required for optimal results.
Tested Applications
WB
Host or Source
Rabbit
Preservative
0.5 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Rabbit IgG

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