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ATF6 Antibody-

CAT: 0013-GTR18080821-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18080821-01Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ER stress can cause the accumulation of unfolded proteins and lead to the activation of the UPR (unfolded proetin response) . Cells have developed an intracellular signaling pathway to deal with this stress, and Activating Transcription Factor 6 (ATF6) is a major transducer of the UPR. Upon activation, ATF6 seperates from GPR78 and is cleaved. The ~50 kD cytosolic portion of ATF6 translocates to the nucleus, transmitting the ER stress signal. In the nucleus, ATF6 activates the transcription of UPR-responsive genes by biniding to their ERSE (ER stress response element) region.
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant protein fragment from the N-terminal region of human ATF6 was used as the immunogen for this antibody.
Clonality
Monoclonal
Clone
AF6229
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Protein G purified monoclonal antibody
Dilution
Western blot: 2-4ug/ml (2), Immunohistochemistry (FFPE) : 5ug/ml (1)
References & Citations
Merna Roshdy 1, Doaa A Zaky 2, Samah S Abbas 1, Dalaal M Abdallah Niacin, an innovative protein kinase-C-dependent endoplasmic reticulum stress reticence in murine Parkinson's disease Life Sci, (2024)
Pubmed id
38914304
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
ATF6 is a 670 amino acid protein that migrates in western blot between 70~90 kD due to glycosylation.1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
Tested Applications
IHC-P, WB
Host or Source
Mouse
Preservative
0.5 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
IgG1, kappa

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