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S100P Antibody

CAT: 0800-V5046SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V5046SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
S100P is a 95-amino-acid protein and a member of the S100 family. S100P has been shown to mediate tumor growth, metastasis and invasion through the binding of Ca2+ ions, receptor for advanced glycation end products, cytoskeletal protein ezrin, calcyclin-binding protein/Siah-1-interacting protein and cathepsin D. S100P highly expressed in human placenta, gastrointestinal tract, and esophageal mucosa, but always negative in pancreas and liver. Overexpression of S100P has been detected in several cancers such as breast, colon, prostate, pancreatic and lung carcinomas, and the protein has been functionally implicated in carcinogenic processes. S100P could potentially serve as diagnostic marker, prognostic/predictive indicator and therapy target for different carcinomas.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P25815
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 1-95) from the human protein was used as the immunogen for the S100P antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
S100P/7373
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the S100P antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This S100P antibody is available for research use only.
Storage Conditions
Aliquot the S100P antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the S100P antibody should be determined by the researcher.
Location
Nucleus, Cytoplasm
Image Legend
Western blot testing of human SK-BR-3 cell lysate with S100P antibody (clone S100P/7373) . Predicted molecular weight ~10 kDa.

UniProtKB · P25815

Protein S100-P

S100P_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P25815
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
S100P
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5J7W2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Cellular component

Cell membraneCell projectionCytoplasmMembraneNucleus

Domain

Repeat

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