IDH1 Recombinant Antibody / Isocitrate Dehydrogenase (R132H mutant)

IDH1 Recombinant Antibody / Isocitrate Dehydrogenase (R132H mutant)

• Description: IDH1 R132H antibody binds to IDH1-mutated protein, but does not bind the wild-type IDH1 protein. IDH1 R132H point mutations are frequently seen in World Health Organization grade II and III gliomas and are believed to constitute an early step in tumorigenesis. IDH1 R132H can be used as a diagnostic marker to help differentiate infiltrating gliomas from gliosis, and as a prognostic marker for gliomas and secondary glioblastoma multiforme. IDH1 R132H antibody shows strong cytoplasmic staining and weaker nuclear staining in tumor cells with the R132H-mutated peptide. Diffuse staining of the fibrillary tumor matrix is also seen.
• CAS Number: 9000-83-3
• UniProt: O75874
• Host: Rabbit
• Immunogen: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the IDH1-R132H Mutant antibody.
• Clonality: Monoclonal
• Isotype: IgG κ
• Type: Recombinant
• Applications: IHC-P
• Format: Purified
• Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Reconstitution: Aliquot the IDH1-R132H Mutant antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This IDH1-R132H Mutant antibody is available for research use only.