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SATB2 Antibody

CAT: 0800-V4930SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V4930SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SATB2 is a DNA binding protein that specifically binds nuclear matrix attachment regions. It is involved in transcription regulation and chromatin remodeling. SATB2 expression in colorectal carcinomas (CRC) is correlated with good prognosis and in laryngeal squamous cell carcinoma it functions as a tumor suppressor wherein loss of expression is positively correlated with high tumor grade and recurrence. Moreover, SATB2, in combination with CK20, could identify almost all CRC s. Upper gastrointestinal (GI) carcinomas and pancreatic ductal carcinomas are usually negative for SATB2, and ovarian carcinomas, lung adenocarcinomas, and adenocarcinomas from other origin are rarely positive for SATB2. Additionally, SATB2 antibody can identify neuroendocrine neoplasms of colon and rectum because SATB2 is usually negative in neuroendocrine neoplasms of the GI tract, pancreas, and lung. More recently, it has been reported that SATB2 is a sensitive marker for tumors with osteoblastic differentiation.
CAS Number
9000-83-3
Specifications
ELISA (Order BSA-free format for coating)
UniProt
Q9UPW6
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 150-350) from the human protein was used as the immunogen for the SATB2 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RSATB2/8635
Type
Recombinant
Applications
ELISA
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the SATB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This SATB2 antibody is available for research use only.
Storage Conditions
Aliquot the SATB2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the SATB2 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
SDS-PAGE analysis of purified, BSA-free SATB2 antibody (clone rSATB2/8635) as confirmation of integrity and purity.

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