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TROP2 Antibody / TACSTD2

CAT: 0800-V4666-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V4666-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TACSTD2/TROP2 is a cell surface glycoprotein receptor. It is a single pass type I membrane protein containing one thyroglobulin type-1 domain, an epidermal growth factor-like repeat, a phosphatidylinositol binding site and tyrosine phosphorylation sites near the C-terminus. It plays a role in transducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multi-stratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P09758
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant fragment of human TACSTD2 protein was used as the immunogen for the TROP2 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
TACSTD2/7348R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the TROP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TROP2 antibody is available for research use only.
Storage Conditions
Aliquot the TROP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the TROP2 antibody should be determined by the researcher.
Location
Cell Surface
Image Legend
IHC staining of FFPE human prostate carcinoma tissue with TACSTD2 antibody (clone TACSTD2/7348R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P09758

Tumor-associated calcium signal transducer 2

TACD2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09758
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TACSTD2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q15658, Q6FG48, Q7Z7Q4, Q96QD2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

AmyloidMembrane

Disease

AmyloidosisCorneal dystrophy

PTM

Disulfide bondGlycoprotein

Biological process

Sensory transductionVision

Domain

SignalTransmembraneTransmembrane helix

Molecular function

Tumor antigen
Product Datasheet
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