CD162 Recombinant Antibody / P selectin glycoprotein ligand 1 / PSGL-1

CD162 Recombinant Antibody / P selectin glycoprotein ligand 1 / PSGL-1

• Description: CD162 glycoprotein functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.
• CAS Number: 9000-83-3
• UniProt: Q14242
• Host: Rabbit
• Immunogen: Recombinant full-length human protein was used as the immunogen for the CD162 antibody.
• Clonality: Monoclonal
• Isotype: IgG κ
• Type: Recombinant
• Applications: IHC-P
• Format: Purified
• Buffer: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Reconstitution: Aliquot the CD162 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This CD162 antibody is available for research use only.