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CRYAB Antibody

CAT: 0800-V4192-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V4192-100UGSize:100 µg
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Description
Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into Alpha, beta and gamma families, and the beta- and gamma-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha-crystallins consist of three gene products, AlphaA-, AlphaB- and AlphaC-crystallin, which are members of the small heat shock protein family (HSP 20) . Alpha-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, Alpha-crystallins do not renature these proteins. Expression of AlphaA-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC) . The human AlphaB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of AlphaB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Western blot: 2-4 µg/mL
UniProt
P02511
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human full-length CRYAB protein was used as the immunogen for the CRYAB antibody.
Clonality
Monoclonal
Isotype
IgG2 κ
Clone
CRYAB/4662
Applications
IHC-P, WB
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the CRYAB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CRYAB antibody is available for research use only.
Storage Conditions
Aliquot the CRYAB antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the CRYAB antibody should be determined by the researcher.
Location
Cytoplasm, Nucleus
Image Legend
IHC staining of FFPE human skeletal muscle tissue with Crystallin Alpha B antibody (clone CRYAB/4662) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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