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Ki-67 Antibody

CAT: 0800-V4124-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V4124-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ki-67 antigen is a nuclear, non-histone protein that is present in all stages of the cell cycle except G0. This characteristic makes Ki-67 an excellent marker for proliferating cells and is commonly used as one of the prognostic factors in cancer studies. A correlation has been demonstrated between Ki-67 index and the histo-pathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors. Ki-67 labeling index has been shown to be a prognostic marker in a number of neoplasms including grade II astrocytoma, oligodendroglioma, colon carcinoma, and breast carcinoma. In general, Ki-67 is a good marker of proliferating cell populations.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P46013
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human Ki67 protein fragment (within amino acids 2293-2478) was used as the immunogen for the Ki-67 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
MKI67/6571
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Ki-67 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Ki-67 antibody is available for research use only.
Storage Conditions
Aliquot the Ki-67 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Ki-67 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
IHC staining of FFPE human tonsil tissue with Ki67 antibody (clone MKI67/6571) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P46013

Proliferation marker protein Ki-67

KI67_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P46013
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MKI67
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5VWH2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycle

Cellular component

ChromosomeNucleus

Molecular function

DNA-binding

Domain

Repeat

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Alternative Products

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MBS2169887-01Monoclonal Antibody to Ki-67 Protein (Ki-67)
CAU36144-01Ki-67 Protein (Ki-67) Monoclonal Antibody
CAU24782-01Ki-67 Protein (Ki-67) Polyclonal Antibody
TRV-004422-01Polyclonal Antibody to Ki-67 Protein (Ki-67)
030367Ki-67 (Antigen KI-67, MKI67, Ki67, Ki 67)
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