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PTEN Antibody

CAT: 0800-V4106-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V4106-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PTEN (phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase) contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. It was identified as a tumor suppressor that is mutated in a large number of cancers, including sporadic brain, breast, kidney, and prostate cancers.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P60484
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human PTEN protein was used as the immunogen for the PTEN antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
PTEN/2159
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the PTEN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PTEN antibody is available for research use only.
Storage Conditions
Aliquot the PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the PTEN antibody should be determined by the researcher.
Location
Cytoplasm, Nucleus
Image Legend
Analysis of a HuProt (TM) microarray containing more than 19,000 full-length human proteins using PTEN antibody (clone PTEN/2159) . Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a mAb to its intended target. A mAb is considered to specific to its intended target, if the mAb has an S-score of at least 2.5. For example, if a mAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that mAb to protein X is equal to 29.

UniProtKB · P60484

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

PTEN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P60484
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTEN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.16, 3.1.3.48, 3.1.3.67
Processing
—
Secondary accessions
B2R904, F2YHV0, O00633, O02679, Q6ICT7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative initiationAlternative splicing

Biological process

ApoptosisLipid metabolismNeurogenesis

Disease

Autism spectrum disorderDisease variantTumor suppressor

Cellular component

Cell projectionCytoplasmNucleusSecretedSynapse

Molecular function

HydrolaseProtein phosphatase

Ligand

Lipid-binding

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CatalogName
GTR18155606-01PTEN Antibody

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