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PTEN Antibody

CAT: 0800-V4105-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V4105-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PTEN (phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase) contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. It was identified as a tumor suppressor that is mutated in a large number of cancers, including sporadic brain, breast, kidney, and prostate cancers.
CAS Number
9007-83-4
Specifications
ELISA (Order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P60484
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human PTEN protein was used as the immunogen for the PTEN antibody.
Clonality
Monoclonal
Isotype
IgG κ
Clone
PTEN/7345
Applications
ELISA, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the PTEN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PTEN antibody is available for research use only.
Storage Conditions
Aliquot the PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the PTEN antibody should be determined by the researcher.
Location
Cytoplasm, Nucleus
Image Legend
IHC staining of FFPE human prostate carcinoma tissue with PTEN antibody (clone PTEN/7345) at 2ug/ml. Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P60484

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

PTEN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P60484
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTEN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.16, 3.1.3.48, 3.1.3.67
Processing
—
Secondary accessions
B2R904, F2YHV0, O00633, O02679, Q6ICT7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative initiationAlternative splicing

Biological process

ApoptosisLipid metabolismNeurogenesis

Disease

Autism spectrum disorderDisease variantTumor suppressor

Cellular component

Cell projectionCytoplasmNucleusSecretedSynapse

Molecular function

HydrolaseProtein phosphatase

Ligand

Lipid-binding

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