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UBE2N Antibody

CAT: 0800-RQ7424Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ7424Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ubiquitin-conjugating enzyme E2 N is a protein that in humans is encoded by the UBE2N gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunofluorescence: 5 µg/mL, Flow cytometry: 1-3ug/million cells, Immunohistochemistry (FFPE) : 2-5 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P61088
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E. coli-derived recombinant human protein (amino acids Q13-I152) was used as the immunogen for the UBE2N antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IF, FACS, IHC-P, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the UBE2N antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This UBE2N antibody is available for research use only.
Storage Conditions
After reconstitution, the UBE2N antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the UBE2N antibody should be determined by the researcher.
Location
Nuclear, cytoplasmic
Image Legend
IHC staining of FFPE human cervical cancer tissue with UBE2N antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · P61088

Ubiquitin-conjugating enzyme E2 N

UBE2N_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61088
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
UBE2N
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.23
Processing
—
Secondary accessions
Q16781, Q53Y81
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondIsopeptide bondUbl conjugation

Cellular component

CytoplasmNucleus

Biological process

DNA damageDNA repairUbl conjugation pathway

Molecular function

Transferase

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