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Daphnetin (Standard)

CAT: 0804-HY-N0281R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0281R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4].
CAS Number
486-35-1
Product Name Alternative
7,8-Dihydroxycoumarin (Standard)
UNSPSC
12352005
Target
Akt; AMPK; Apoptosis; Autophagy; Bcl-2 Family; Caspase; EGFR; mTOR; Parasite; PARP; PKA; PKC; Reactive Oxygen Species (ROS) ; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Others; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/daphnetin-standard.html
Smiles
O=C1C=CC2=CC=C(O)C(O)=C2O1
Molecular Formula
C9H6O4
Molecular Weight
178.14
References & Citations
[1]Fan X, et, al. Daphnetin triggers ROS-induced cell death and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway in ovarian cancer. Phytomedicine. 2021 Feb;82:153465.|[2]Zhang L, et, al. Daphnetin protects against cisplatin-induced nephrotoxicity by inhibiting inflammatory and oxidative response. Int Immunopharmacol. 2018 Dec;65:402-407.|[3]Wang QM, et, al. The schizontocidal activity of daphnetin against malaria parasites in vitro and in vivo. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2000;18 (4) :204-6.|[4]Yang EB, Zhao YN, Zhang K, Mack P. Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor. Biochem Biophys Res Commun. 1999 Jul 14;260 (3) :682-5.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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