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Conoidin A

CAT: 0804-HY-116090-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116090-01Size:25 mg
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Description
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. Conoidin A also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII) [1][2]. Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease[3].
CAS Number
18080-67-6
UNSPSC
12352005
Hazard Statement
H302, H314
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/conoidin-a.html
Concentration
10mM
Purity
99.32
Solubility
DMSO : 14.29 mg/mL (ultrasonic)
Smiles
[O-][N+]1=C(C(CBr)=[N+](C2=C1C=CC=C2)[O-])CBr
Molecular Formula
C10H8Br2N2O2
Molecular Weight
347.99
Precautions
H302, H314
References & Citations
[1]Jeralyn D Haraldsen, et al. IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II. Org Biomol Chem. 2009;7:3040-3048.|[2]Gu Liu, et al. Optimisation of conoidin A, a peroxiredoxin inhibitor. ChemMedChem. 2010 Jan;5 (1) :41-5.|[3]Bo Wei, et al. Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II. Br J Pharmacol
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Toxoplasma

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Alternative Products

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C4293-50Conoidin A
A22167-500Conoidin A 500mg
A22167-25Conoidin A 25mg
A22167-50Conoidin A 50mg
A22167-100Conoidin A 100mg
A22167-10mM-DConoidin A 10mM * 1mL in DMSO

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