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Dencatistat

CAT: 0804-HY-157783-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-157783-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dencatistat (P115) is an inhibitor of Cytidine Triphosphate Synthase 1 (CTPS1) with an IC50 value of ≤ 0.1 μM. Dencatistat can be used for research on cancer (such as leukemia and lymphoma), inflammatory skin diseases (such as psoriasis), or multiple sclerosis[1].
CAS Number
2377000-84-3
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ctps1-in-2.html
Purity
99.04
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1(CCOCC1)C2=NC(NS(=O)(C3CC3)=O)=NC=C2)NC4=NC=C(C5=CN=CC(OCC)=N5)C=C4
Molecular Formula
C24H27N7O5S
Molecular Weight
525.58
References & Citations
[1]Quddus, et al. "N- (4- (5-chloropyridin-3-yl) phenyl) -2- (2- (cyclopropanesulfonamido) pyrimidin-4-yl) butanamide derivatives and related compounds as human CTPS1 inhibitors for the treatment of proliferative diseases." U.S. Patent. WO2019179652 A1. 2023-03-23
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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