Ancitabine

• Description:

  Ancitabine is the precursor of the anticancer agent Cytarabine (HY-13605), which targets targets related to cell metabolism and proliferation. Ancitabine can inhibit tumor cell proliferation, interfere with the DNA synthesis process of tumor cells, and prevent cell division. Under alkaline pH conditions, Ancitabine can be quantitatively converted into Cytarabine and can be used in the study of cancers such as colorectal cancer[1][2].

• Product Name Alternative:

  Cyclocytidine; Cyclo-CMP

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H320

• Target:

  Autophagy; CMV; DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Autophagy; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ancitabine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC[C@@H]1[C@@H] (O) [C@@] (O2) ([H]) [C@@] (N (C2=N3) C=CC3=N) ([H]) O1

• Molecular Formula:

  C9H11N3O4

• Molecular Weight:

  225.20

• Precautions:

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations:

  [1]Aftab O, et al. Detection of cell aggregation and altered cell viability by automated label-free video microscopy: a promising alternative to endpoint viability assays in high-throughput screening. J Biomol Screen. 2015 Mar;20 (3) :372-81.|[2]Kirsch LE, et al. Aqueous conversion kinetics and mechanisms of ancitabine, a prodrug of the antileukemic agent cytarabine. J Pharm Sci. 1984 Jul;73 (7) :896-902.x

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  31698-14-3