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2-Hydroxyestradiol

CAT: 0804-HY-124489-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124489-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[1][3].
CAS Number
362-05-0
UNSPSC
12352005
Hazard Statement
H351
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/2-hydroxyestradiol.html
Purity
98.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(C=C(C2=C1)CC[C@@]3([C@@]2(CC[C@]4([C@]3(CC[C@@H]4O)[H])C)[H])[H])O
Molecular Formula
C18H24O3
Molecular Weight
288.38
Precautions
H351
References & Citations
[1]C H Van Aswegen, et al. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem. 1989 Apr;32 (4) :485-92.|[2]S P Tofovic, et al. 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats. J Pharmacol Exp Ther. 2001 Dec;299 (3) :973-7.|[3]Yeon-Jin Hurh, et al. 2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells. J Toxicol Environ Health A. 2004 Dec;67 (23-24) :1939-53.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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