Selamectin (Standard)

CAT: 0804-HY-107212R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107212R-01Size:5 mg
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Description
Selamectin (Standard) is the analytical standard of Selamectin. This product is intended for research and analytical applications. Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC50 of 120 nM[1][2].
CAS Number
[220119-17-5]
UNSPSC
12352005
Target
Bacterial; Chloride Channel; Parasite; P-glycoprotein; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/selamectin-standard.html
Smiles
O[C@@]12[C@@]3([H])/C(C(C)=C[C@@]1([H])C(O[C@]4([H])C[C@]5(O[C@@](C/C=C(C)/[C@@H](O[C@@]6([H])C[C@@H]([C@@H](O)[C@H](C)O6)OC)[C@@H](C)/C=C/C=C2\CO3)([H])C4)O[C@H](C7CCCCC7)[C@@H](C)CC5)=O)=N\O
Molecular Formula
C43H63NO11
Molecular Weight
769.96
References & Citations
[1]Patsharaporn T Sarasombath, et al. First study of topical selamectin efficacy for treating cats naturally infected with Brugia malayi and Brugia pahangi under field conditions. Parasitol Res. 2019 Apr;118 (4) :1289-1297.|[2]J Griffin, et al. Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein. J Vet Pharmacol Ther. 2005 Jun;28 (3) :257-65.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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