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CSPG4 Antibody / NG2

CAT: 0013-GTR18082659-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082659-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2 (VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. [UniProt]
UniProt
Q6UVK1
Reactivity
Human
Immunogen
A 375P cells crude extract was used as the immunogen for this CSPG4 antibody
Clonality
Monoclonal
Clone
LHM 2
Conjugation
Unconjugated
Field of Research
Cardiovascular Research
Purification
Protein G affinity chromatography
Dilution
Immunofluorescence: 1-2ug/ml, Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the CSPG4 antibody should be determined by the researcher.
Tested Applications
IF, IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1, kappa

UniProtKB · Q6UVK1

Chondroitin sulfate proteoglycan 4

CSPG4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q6UVK1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CSPG4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
D3DW77, Q92675
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

AngiogenesisDifferentiationTissue remodeling

Cellular component

Cell membraneCell projectionMembrane

Molecular function

Developmental proteinTransducer

PTM

Disulfide bondGlycoproteinPhosphoproteinProteoglycan

Domain

RepeatSignalTransmembraneTransmembrane helix

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