Indoline

• Description:

  Indoline is a derivative of Indole (HY-W001132) . Indoline can use as the basic structure for CD4 mimetic compounds (CD4mcs), which triggers conformational changes of the HIV-1 envelope glycoprotein (Env) in advance, and causes viral inactivation. Indoline binds to gp120. Indoline CD4mcs can inhibit HIV-1AD8 with an IC50 in the micromolar range[1].

• UNSPSC:

  12352200

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  HIV

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/indoline.html

• Concentration:

  10mM

• Purity:

  99.89

• Solubility:

  DMSO : ≥ 200 mg/mL

• Smiles:

  C12=C(NCC2)C=CC=C1

• Molecular Formula:

  C8H9N

• Molecular Weight:

  119.17

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Fritschi CJ, et al., Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proc Natl Acad Sci U S A. 2023 Mar 28;120 (13) :e2222073120.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [496-15-1]