D-myo-Inositol 1,4,5-trisphosphate (tripotassium)

D-myo-Inositol 1,4,5-trisphosphate (tripotassium)

• CAS Number: 141611-11-2
• UNSPSC Description: D-myo-Inositol 1,4,5-trisphosphate tripotassium, a second messenger, elicits Ca2+ mobilization. D-myo-Inositol 1,4,5-trisphosphate tripotassium inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2)[1].
• Target Antigen: Calcium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/d-myo-inositol-1-4-5-trisphosphate-tripotassium.html
• Solubility: H2O : 50 mg/mL (ultrasonic;warming)
• Smiles: O[C@H]1[C@H]([C@@H]([C@H]([C@@H]([C@H]1O)OP(O)(O[K])=O)OP(O)(O[K])=O)O)OP(O)(O[K])=O
• Molecular Weight: 534.37
• References & Citations: [1]D M Gou, et al. D-myo-inositol 1,4,5-trisphosphate analogues as useful tools in biochemical studies of intracellular calcium mobilization. Bioorg Med Chem. 1994 Jan;2(1):7-13. |[2]M E Cifuentes, et al. D-myo-inositol 1,4,5-trisphosphate inhibits binding of phospholipase C-delta 1 to bilayer membranes. J Biol Chem. 1994 Jan 21;269(3):1945-8.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported