D-myo-Inositol 1,4,5-trisphosphate (tripotassium)

• UNSPSC Description:

  D-myo-Inositol 1,4,5-trisphosphate tripotassium, a second messenger, elicits Ca2+ mobilization. D-myo-Inositol 1,4,5-trisphosphate tripotassium inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2)[1].

• Target Antigen:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/d-myo-inositol-1-4-5-trisphosphate-tripotassium.html

• Solubility:

  H2O : 50 mg/mL (ultrasonic;warming)

• Smiles:

  O[C@H]1[C@H]([C@@H]([C@H]([C@@H]([C@H]1O)OP(O)(O[K])=O)OP(O)(O[K])=O)O)OP(O)(O[K])=O

• Molecular Weight:

  534.37

• References & Citations:

  [1]D M Gou, et al. D-myo-inositol 1,4,5-trisphosphate analogues as useful tools in biochemical studies of intracellular calcium mobilization. Bioorg Med Chem. 1994 Jan;2(1):7-13. |[2]M E Cifuentes, et al. D-myo-inositol 1,4,5-trisphosphate inhibits binding of phospholipase C-delta 1 to bilayer membranes. J Biol Chem. 1994 Jan 21;269(3):1945-8.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  141611-11-2