Osivelotor

CAT: 0804-HY-148788-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-148788-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Osivelotor is an orally effective small molecule. Osivelotor is an allosteric regulator of deoxyhemoglobin S (HbS) . Osivelotor increases the affinity of HbS to oxygen, inhibits HbS polymerization, and thus prevents erythrocyte sickling in the blood. Osivelotor can be used for research of sickle cell disease (SCD) [1] [2].

CAS Number

2417955-18-9

Product Name Alternative

GBT-601; GBT-021601

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/osivelotor.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(N=CC=C1)CCO)N2[C@@H](COCC2)COC3=C(C(O)=CC=C3)C=O

Molecular Formula

C20H22N2O6

Molecular Weight

386.40

References & Citations

[1]WHO Drug Information-World Health Organization (WHO) .|[2]Dufu K, et al. GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model. Br J Haematol. 2023 Jul;202 (1) :173-183.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 3

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Catalog	Name
E4761-01	Osivelotor

Osivelotor

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