TCL053

CAT: 0804-HY-147332-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-147332-01Size:5 mg
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Description
TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle[1][2].
CAS Number
[2361162-70-9]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Liposome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tcl053.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(C)CCCC(OCC(COC(CCCCCCC/C=C\CCCC)=O)(COC(CCCCCCC/C=C\CCCC)=O)COC(CCCCCCC/C=C\CCCC)=O)=O
Molecular Formula
C53H95NO8
Molecular Weight
874.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Kenjo E, et al. Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice. Nat Commun. 2021 Dec 8;12 (1) :7101.|[2]Cationic lipid. JPWO2019131839A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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