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Mannan

CAT: 0804-HY-W145667-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W145667-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mannan is an orally active polysaccharide compound that binds to the mannose receptor (MR). Mannan promotes bacterial uptake and endosomal degradation by binding to MR, thereby enhancing the production of IL-12 in immune cells. Mannan enhances ROS production. Mannan modulates immunity, inhibits Aflatoxin B1 -induced toxicity, and reduces lipid[1][2][3][4].
CAS Number
9036-88-8
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Endogenous Metabolite; Glycosidase; Interleukin Related; Reactive Oxygen Species (ROS)
Type
Biochemical Assay Reagents
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mannan.html
Purity
98.00
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
[Mannan]
Precautions
H302, H315, H319, H335
References & Citations
[1]Mathiesen R, et al. Mannan Enhances IL-12 Production by Increasing Bacterial Uptake and Endosomal Degradation in L. acidophilus and S. aureus Stimulated Dendritic Cells. Front Immunol. 2019 Nov 15;10:2646.|[2]Madrigal-Santillán E, et al. Inhibitory effect of mannan on the toxicity produced in mice fed aflatoxin B1 contaminated corn. Arch Environ Contam Toxicol. 2007 Oct;53 (3) :466-72.|[3]Funayama H, et al. Pharmacological characterization of anaphylaxis-like shock responses induced in mice by mannan and lipopolysaccharide. Int Immunopharmacol. 2009 Dec;9 (13-14) :1518-24.|[4]Goncharova NV, et al. Hypolipidemic Effect of Mannan in Mice with Acute Lipemia Induced by Poloxamer 407. Bull Exp Biol Med. 2016 Nov;162 (1) :18-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
Phase 2

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