Mannan

• Description:

  Mannan is an orally active polysaccharide compound that binds to the mannose receptor (MR) . Mannan promotes bacterial uptake and endosomal degradation by binding to MR, thereby enhancing the production of IL-12 in immune cells. Mannan enhances ROS production. Mannan modulates immunity, inhibits Aflatoxin B1 (HY-N6615) -induced toxicity, and reduces lipid[1][2][3][4].

• UNSPSC:

  12352200

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Bacterial; Endogenous Metabolite; Glycosidase; Interleukin Related; Reactive Oxygen Species (ROS)

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Infection; Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/mannan.html

• Purity:

  98.00

• Solubility:

  H2O : 50 mg/mL (ultrasonic)

• Smiles:

  [Mannan]

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Mathiesen R, et al. Mannan Enhances IL-12 Production by Increasing Bacterial Uptake and Endosomal Degradation in L. acidophilus and S. aureus Stimulated Dendritic Cells. Front Immunol. 2019 Nov 15;10:2646.|[2]Madrigal-Santillán E, et al. Inhibitory effect of mannan on the toxicity produced in mice fed aflatoxin B1 contaminated corn. Arch Environ Contam Toxicol. 2007 Oct;53 (3) :466-72.|[3]Funayama H, et al. Pharmacological characterization of anaphylaxis-like shock responses induced in mice by mannan and lipopolysaccharide. Int Immunopharmacol. 2009 Dec;9 (13-14) :1518-24.|[4]Goncharova NV, et al. Hypolipidemic Effect of Mannan in Mice with Acute Lipemia Induced by Poloxamer 407. Bull Exp Biol Med. 2016 Nov;162 (1) :18-22.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  Phase 2

• CAS Number:

  [9036-88-8]