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Mannan

CAT: 0804-HY-W145667-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W145667-01Size:50 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mannan is an orally active polysaccharide compound that binds to the mannose receptor (MR) . Mannan promotes bacterial uptake and endosomal degradation by binding to MR, thereby enhancing the production of IL-12 in immune cells. Mannan enhances ROS production. Mannan modulates immunity, inhibits Aflatoxin B1 (HY-N6615) -induced toxicity, and reduces lipid[1][2][3][4].
CAS Number
[9036-88-8]
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Endogenous Metabolite; Glycosidase; Interleukin Related; Reactive Oxygen Species (ROS)
Type
Biochemical Assay Reagents
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mannan.html
Purity
98.00
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
[Mannan]
Precautions
H302, H315, H319, H335
References & Citations
[1]Mathiesen R, et al. Mannan Enhances IL-12 Production by Increasing Bacterial Uptake and Endosomal Degradation in L. acidophilus and S. aureus Stimulated Dendritic Cells. Front Immunol. 2019 Nov 15;10:2646.|[2]Madrigal-Santillán E, et al. Inhibitory effect of mannan on the toxicity produced in mice fed aflatoxin B1 contaminated corn. Arch Environ Contam Toxicol. 2007 Oct;53 (3) :466-72.|[3]Funayama H, et al. Pharmacological characterization of anaphylaxis-like shock responses induced in mice by mannan and lipopolysaccharide. Int Immunopharmacol. 2009 Dec;9 (13-14) :1518-24.|[4]Goncharova NV, et al. Hypolipidemic Effect of Mannan in Mice with Acute Lipemia Induced by Poloxamer 407. Bull Exp Biol Med. 2016 Nov;162 (1) :18-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
Phase 2

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