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Alamethicin

CAT: 0804-HY-N6708-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6708-01Size:1 mg
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Description
Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes[1][2].
CAS Number
27061-78-5
UNSPSC
12352209
Hazard Statement
H301
Target
Antibiotic; Bacterial
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/alamethicin.html
Purity
99.66
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C(C(NC([C@@H](NC(CNC(C(NC([C@@H](NC(C(NC([C@@H](NC([C@@H](NC(C(NC([C@@H](NC(C(NC(=O)[C@H]1N(C(C(NC(C)=O)(C)C)=O)CCC1)(C)C)=O)C)=O)(C)C)=O)C)=O)CCC(N)=O)=O)(C)C)=O)[C@H](C)C)=O)(C)C)=O)=O)CC(C)C)=O)(C)C)(=O)N2[C@H](C(N[C@H](C(NC(C(NC(C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)CO)=O)CCC(N)=O)=O)CCC(O)=O)=O)(C)C)=O)(C)C)=O)[C@@H](C)C)=O)CCC2
Molecular Formula
C92H150N22O25
Molecular Weight
1964.34
Precautions
H301
References & Citations
[1]Olga S.Ostroumova, et al. Chapter Six-Modifiers of Membrane Dipole Potentials as Tools for Investigating Ion Channel Formation and Functioning. International Review of Cell and Molecular Biology Volume 315, 2015, Pages 245-297.|[2]Barns KJ, et al. Single-cell, time-resolved study of the effects of the antimicrobial peptide alamethicin on Bacillus subtilis. Biochim Biophys Acta. 2016 Apr;1858 (4) :725-32.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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