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RO5101576

CAT: 0804-HY-121621Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-121621Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RO5101576 is a potent LTB4 receptor antagonist with activity to inhibit LTB4-induced calcium mobilization and chemotaxis of human neutrophils. RO5101576 significantly attenuated LTB4-induced pulmonary eosinophilia in guinea pigs. RO5101576 inhibited allergen- and ozone-induced pulmonary neutrophilia in nonhuman primates with efficacy comparable to that of budesonide. RO5101576 had no effect on LPS-induced neutrophilia in guinea pigs and cigarette smoke-induced neutrophilia in mice and rats. RO5101576 performed well in toxicology studies and was well tolerated[1].
CAS Number
1123155-95-2
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ro5101576.html
Smiles
O=C(CCCOC1=CC=CC(CCCCCCOC2=CC(C3=CSC=C3)=CC(C4=CC=C5OCOC5=C4)=C2)=C1CCC(O)=O)O
Molecular Formula
C36H38O8S
Molecular Weight
630.75
References & Citations
[1]Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
MBS5778279RO5101576

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