Fluorescent Human EDNRB Full Length Protein (VLP)

Fluorescent Human EDNRB Full Length Protein (VLP)

• Background: Endothelin Receptor B (EDNRB) is a type of G protein-coupled Receptor with the N-terminus located outside the cell. It's widespread in the human body. EDNRB binds to ET and transmits information into the cell through the intracellular Ca2+ phospholipid-dependent protein kinase second messenger system, which promotes the rapid release of calcium in the endoplasmic reticulum and sarcoplasmic reticulum, resulting in the rapid increase of intracellular calcium concentration. Endothelin exerts its biological effects through its receptor (ETR). Endothelin and ETR constitute the endothelin axis. Endothelin axis has pro-tumor effects in various tumors including malignant melanoma (MM), including promoting tumor growth, anti-apoptosis, promoting angiogenesis and promoting tumor metastasis.
• Description: Fluorescent Human EDNRB Full Length Protein (VLP) (EDB-HF2G4) is expressed from human 293 cells (HEK293). It contains AA Glu 27 - Ser 442 (Accession # P24530-1).
• Specifications: This protein carries a GFP tag.
• Expression Region: Glu 27 - Ser 442
• Host: HEK 293
• Target: EDNRB
• Conjugation: GFP Fusion
• Tag: GFP Tag
• Source: Human
• Stability: The product MUST be stored at -70°C or lower upon receipt; -70°C for 12 months under sterile conditions.
• Endotoxin: 1.0 EU per μg
• Bioactivity: Immobilized Fluorescent Human EDNRB Full Length Protein (VLP) (Cat. No. EDB-HF2G4) at 2 μg/mL (100 μL/well) can bind Anti-EDNRB Antibody, Human IgG1 with a linear range of 0.001-0.003 μg/mL (QC tested).
• Format: Liquid
• Buffer: PBS, Arginine, pH7.4
• Additives: Trehalose
• Shipping Conditions: Dry ice
• Storage Conditions: -70°C, aviod light