4-Hydroxyatomoxetine

• Description :

  4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6) . Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively) [1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H319-H361

• Target :

  Adrenergic Receptor; Drug Metabolite

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/4-hydroxyatomoxetine.html

• Purity :

  97.04

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  OC1=CC=C(O[C@@H](C2=CC=CC=C2)CCNC)C(C)=C1

• Molecular Formula :

  C17H21NO2

• Molecular Weight :

  271.36

• Precautions :

  P264-P270-P280-P305+P351+P338-P330-P405-P501

• References & Citations :

  [1]JT Brown, Single Dose Pharmacokinetics of Atomoxetine in Children.|[2]Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27 (5) :699-711.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [435293-66-6]