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CSP1

CAT: 0804-HY-P2454-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2454-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CSP1 is a potent and selective ComD1 receptor agonist, with an IC50 of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating quorum sensing (QS) . CSP1 can act as an antibacterial agent[1][2].
CAS Number
172889-49-5
UNSPSC
12352209
Target
Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/csp1.html
Purity
98.26
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
NCCCC[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCSC)NC([C@@H](N)CCC(O)=O)=O)=O)=O)=O)=O)=O)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O
Molecular Formula
C103H168N30O24S
Molecular Weight
2242.69
References & Citations
[1]Yang Y, et, al. Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumonia. Biochemistry. 2018 Sep 11;57 (36) :5359-5369.|[2]Johnsborg O, et, al. A hydrophobic patch in the competence-stimulating Peptide, a pneumococcal competence pheromone, is essential for specificity and biological activity. J Bacteriol. 2006 Mar; 188 (5) : 1744-9.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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