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Stauprimide

CAT: 0804-HY-N6747-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6747-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Stauprimide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation. Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which results in down-regulation of MYC transcription[1].
CAS Number
154589-96-5
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Autophagy; c-Myc
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stauprimide.html
Purity
99.45
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
C[C@@]([C@@H]1OC)(O[C@](N2C3=CC=CC=C43)([H])C[C@H]1N(C)C(C5=CC=CC=C5)=O)N6C(C2=C4C(C7=O)=C8C(N7)=O)=C8C9=C6C=CC=C9
Molecular Formula
C35H28N4O5
Molecular Weight
584.62
Precautions
H315, H319, H335
References & Citations
[1]Bouvard C, et al. Small molecule selectively suppresses MYC transcription in cancer cells. Proc Natl Acad Sci USA. 2017 Mar 28;114 (13) :3497-3502.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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