3,5-Dinitrocatechol

• Description :

  3,5-Dinitrocatechol (OR-486) is a potent catechol-O-methyltransferase inhibitor, with an IC50 of 12 nM. 3,5-Dinitrocatechol can be used in the preparation of the molybdenum (VI) - 3,5-Dinitrocatechol complex[1][2][3].

• Product Name Alternative :

  OR-486; 3,5-Dinitropyrocatechol

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  COMT

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/3-5-dinitrocatechol.html

• Purity :

  99.72

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  OC1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1O

• Molecular Formula :

  C6H4N2O6

• Molecular Weight :

  200.11

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Nissinen E, et, al. Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat. Eur J Pharmacol. 1988 Aug 24;153 (2-3) :263-9. |[2]Yamaki F, et, al. Effects of Catecholamine Metabolites on Beta-Adrenoceptor-Mediated Relaxation of Smooth Muscle: Evaluation in Mouse and Guinea-Pig Trachea and Rat Aorta. Biol Pharm Bull. 2020;43 (3) :493-502. |[3]Stojnova K, et, al. Study on the Complex Equilibria of Molybdenum (VI) with 3,5-Dinitrocatechol and Ditetrazolium Salt. Acta Chim Slov. 2016;63 (3) :654-60.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [7659-29-2]