3,5-Dinitrocatechol

3,5-Dinitrocatechol

• CAS Number: 7659-29-2
• UNSPSC Description: 3,5-Dinitrocatechol (OR-486) is a potent catechol-O-methyltransferase inhibitor, with an IC50 of 12 nM. 3,5-Dinitrocatechol can be used in the preparation of the molybdenum (VI)- 3,5-Dinitrocatechol complex[1][2][3].
• Target Antigen: COMT
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/3-5-dinitrocatechol.html
• Purity: 99.72
• Solubility: DMSO : ≥ 125 mg/mL|H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: OC1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1O
• Molecular Weight: 200.106
• References & Citations: [1]Nissinen E, et, al. Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat. Eur J Pharmacol. 1988 Aug 24;153(2-3):263-9. |[2]Yamaki F, et, al. Effects of Catecholamine Metabolites on Beta-Adrenoceptor-Mediated Relaxation of Smooth Muscle: Evaluation in Mouse and Guinea-Pig Trachea and Rat Aorta. Biol Pharm Bull. 2020;43(3):493-502. |[3]Stojnova K, et, al. Study on the Complex Equilibria of Molybdenum(VI) with 3,5-Dinitrocatechol and Ditetrazolium Salt. Acta Chim Slov. 2016;63(3):654-60.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported