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Raxofelast

CAT: 0804-HY-120485-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120485-01Size:1 mg
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Description
Raxofelast (IRFI-016) is an antioxidant agent in various models of ischemia-reperfusion injury. Raxofelast has antiproliferative activity in H2O2-stimulated rat aortic smooth muscle cells. Raxofelast attenuates the activation of mitogen-activating protein kinase (MAPK), ERK kinase 1, 2 (MEK1,2) and protein kinase C (PKC) without affecting Ras expression[1].
CAS Number
128232-14-4
Product Name Alternative
IRFI-016
UNSPSC
12352005
Target
ERK; p38 MAPK; PKC
Type
Reference compound
Related Pathways
Epigenetics; MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/raxofelast.html
Solubility
10 mM in DMSO
Smiles
O=C(CC1OC2=C(C1)C(C)=C(OC(C)=O)C(C)=C2C)O
Molecular Formula
C15H18O5
Molecular Weight
278.30
References & Citations
[1]Kyung-Hye Lee, et al. Antiproliferative mechanisms of raxofelast (IRFI-016) in H2O2-stimulated rat aortic smooth muscle cells. Eur J Pharmacol. 2004, 484, 2-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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CatalogName
T34268-01Raxofelast

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