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Pip6a

CAT: 0804-HY-P10567Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10567Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pip6a is an arginine-rich cell-penetrating peptide. Pip6a has the ability to deliver associated cargoes across the plasma and endosomal membranes and is stable to serum proteolysis. Pip6a is composed of a hydrophobic core region flanked on each side by arginine-rich domains containing β-alanine and aminohexanoyl spacers. Pip6a-conjugated morpholino phosphorodiamidate oligomer (PMO) dramatically enhanced antisense oligonucleotide (ASO) delivery into striated muscles of myotonic dystrophy (DM1) mice[1].
UNSPSC
12352209
Target
Others
Type
Peptides
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pip6a.html
Smiles
NC(NCCC[C@@H](C(N[C@H](C(NCCC(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(NCCC(N[C@H](C(NCCCCCC(N[C@H](C(NCCC(O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CC(C)C)=O)CC1=CC=CC=C1)=O)CCC(N)=O)=O)CC2=CC=C(O)C=C2)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)NC(CCCCCNC([C@H](CCCNC(N)=N)NC(C)=O)=O)=O)=N
Molecular Formula
C130H231N53O26
Molecular Weight
2952.56
References & Citations
[1]Arnaud F Klein, et al. Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice. J Clin Invest. 2019 Nov 1;129 (11) :4739-4744.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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