N-Desethyl amodiaquine-d5 (dihydrochloride)

N-Desethyl amodiaquine-d5 (dihydrochloride)

• CAS Number: 1216894-33-5
• UNSPSC Description: N-Desethyl amodiaquine-d5 (dihydrochloride) is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].
• Target Antigen: Isotope-Labeled Compounds; Parasite
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Others
• Field of Research: Infection
• Purity: 98.76
• Solubility: H2O : 100 mg/mL (ultrasonic;warming)
• Smiles: ClC1=CC2=C(C(NC3=CC(CNC([2H])(C([2H])([2H])[2H])[2H])=C(O)C=C3)=CC=N2)C=C1.Cl.Cl
• Molecular Weight: 405.76
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported