2-Thiouracil-13C,15N2

• UNSPSC Description:

  2-Thiouracil-13C,15N2 is the 13C, 15N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.

• Target Antigen:

  Isotope-Labeled Compounds; NO Synthase

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Immunology/Inflammation;Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/2-thiouracil-13c-15n2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C=C[15NH]1)[15NH][13C]1=S

• Molecular Weight:

  131.13

• References & Citations:

  [1]Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39(26): p. 5192-201.|[2]Palumbo, A., et al. 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485(2-3): p. 109-12.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported