α-Spinasterol

CAT: 0804-HY-N6962-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N6962-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
α-Spinasterol is an orally taken antagonist of transient receptor potential vanilloid 1 (TRPV1), and it's also an inhibitor of COX-1 and COX-2, with IC50 values of 16.17 μM and 7.76 μM, respectively. α-Spinasterol exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects, has the ability to cross the blood-brain barrier, and can improve diabetes in mice[1][2][3][4][5][6].
CAS Number
[481-18-5]
UNSPSC
12352211
Target
Bacterial; COX; TRP Channel
Type
Natural Products
Related Pathways
Anti-infection; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/alpha-spinasterol.html
Purity
99.15
Solubility
DMF : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC[C@@H](C(C)C)/C=C/[C@@H](C)[C@H]1CC[C@@]2([H])C3=CC[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Formula
C29H48O
Molecular Weight
412.69
References & Citations
[1]Brusco I, et al. α-Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice. Br J Pharmacol. 2017 Dec;174 (23) :4247-4262.|[2]Yang X, et al. A novel method for synthesis of α-spinasterol and its antibacterial activities in combination with ceftiofur. Fitoterapia. 2017 Jun;119:12-19.|[3]Seung I Jeong, et al. alpha-Spinasterol isolated from the root of Phytolacca americana and its pharmacological property on diabetic nephropathy. Planta Med. 2004 Aug;70 (8) :736-9.|[4]Katarzyna Socała, et al. Evaluation of the antidepressant- and anxiolytic-like activity of α-spinasterol, a plant derivative with TRPV1 antagonistic effects, in mice. Behav Brain Res. 2016 Apr 15:303:19-25.|[5]Fabio R M Borges, et al. Anti-inflammatory action of hydroalcoholic extract, dichloromethane fraction and steroid α-spinasterol from Polygala sabulosa in LPS-induced peritonitis in mice. J Ethnopharmacol. 2014;151 (1) :144-50.|[6]Katarzyna Socała, et al. α-Spinasterol, a TRPV1 receptor antagonist, elevates the seizure threshold in three acute seizure tests in mice. Planta Med. 2004 Aug;70 (8) :736-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-1; COX-2

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