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Sunifiram

CAT: 0804-HY-17550-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17550-01Size:5 mg
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Description
Sunifiram (DM-235) is an ampakine-like compound and an agonist of AMPA receptor with oral activity. Sunifiram can increase the release of acetylcholine in the rat cerebral cortex and exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam. Sunifiram is promising for research in neurodegenerative diseases such as mild cognitive impairment (MCI) and Alzheimer's disease (AD)[2][3][4].
CAS Number
314728-85-3
Product Name Alternative
DM-235
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Sunifiram.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : ≥ 2.6 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
CCC(N1CCN(C(C2=CC=CC=C2)=O)CC1)=O
Molecular Formula
C14H18N2O2
Molecular Weight
246.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Galeotti N, et al. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram) . Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368 (6) :538-45.|[2]Moriguchi S, et al. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. Hippocampus. 2013 Jun 3.|[3]Moriguchi S, et al. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. Behav Brain Res. 2013 Apr 1;242:150-7.|[4]Romanelli M N, et al. Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers[J]. CNS Drug Reviews, 2006, 12 (1) : 39-52.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor

Alternative Products

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BA6747-25Sunifiram
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A21037-5Sunifiram 5mg
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