Products for Research Use Only
RegisterLogin

NSC745885

CAT: 0804-HY-119198-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-119198-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NSC745885 an effective anti-tumor agent, shows selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 provides possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers[1][2].
CAS Number
4219-52-7
UNSPSC
12352005
Target
Apoptosis; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc745885.html
Purity
98.0
Solubility
DMSO : < 1 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C2=O)C3=NSN=C3C=C1)C4=C2C=CC=C4
Molecular Formula
C14H6N2O2S
Molecular Weight
266.27
References & Citations
[1]Chen YW, et al.A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo.PLoS One. 2014 Aug 15;9 (8) :e104703.|[2]Tang SH, et al. Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo.Oncotarget. 2014 Nov 15;5 (21) :10342-55.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2

Related Products

CatalogName
HY-123786NSC745887

Alternative Products

CatalogName
GTR19203769-01NSC745885

Popular Products