Biotin-PEG1-azide

Biotin-PEG1-azide

• CAS Number: 1204085-48-2
• UNSPSC Description: Biotin-PEG1-azide is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Biotin-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: ADC Linker
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/biotin-peg1-azide.html
• Purity: 99.88
• Solubility: H2O : 25 mg/mL (ultrasonic)
• Smiles: O=C(CCCC[C@@H]1SC[C@@](N2)([H])[C@]1([H])NC2=O)NCCOCCN=[N+]=[N-]
• Molecular Weight: 356.44
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported