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YSR734

CAT: 0804-HY-161050-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161050-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YSR734 (Compound 21) is a covalent HDAC inhibitor with IC50 values of 110 nM, 154 nM, and 143 nM for HDAC1, HDAC2, and HDAC3, respectively. YSR734 can induce apoptosis in leukemia cells. YSR734 can induce myoblast differentiation and is used in the study of Duchenne muscular dystrophy[1].
CAS Number
3032969-58-4
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ysr734.html
Purity
98.20
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C(NC(C2=CC=C(CNC(OC3CCN(S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)CC3)=O)C=C2)=O)C=CC=C1
Molecular Formula
C26H23F5N4O5S
Molecular Weight
598.54
References & Citations
[1]Raouf YS, et al. Discovery of YSR734: A Covalent HDAC Inhibitor with Cellular Activity in Acute Myeloid Leukemia and Duchenne Muscular Dystrophy. J Med Chem. 2023 Dec 28;66 (24) :16658-16679.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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