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BPKDi

CAT: 0804-HY-118052-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118052-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BPKDi is an inhibitor of PKD. BPKDi inhibits three members of the PKD family, PKD1, PKD2, and PKD3, with IC50 values of 1 nM, 9 nM, and 1 nM, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells[1].
CAS Number
1201673-28-0
Product Name Alternative
d,l-SKF89976A hydrochloride
UNSPSC
12352005
Target
HDAC; PKD
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bpkdi.html
Purity
99.60
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N)C1=CC(C2=CC(NC3CCCCC3)=NC=C2)=NC(N4CCNCC4)=C1
Molecular Formula
C21H28N6O
Molecular Weight
380.49
References & Citations
[1]Lauren Monovich, et al. A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase. FEBS Lett. 2010 Feb 5;584 (3) :631-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKD1; PKD2; PKD3

Alternative Products

CatalogName
MBS5774907BPKDi

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