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LY43578

CAT: 0804-HY-118178-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118178-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY43578 is an orally active aromatase inhibitor. LY43578 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 0.3 and 5 μΜ, respectively. LY43578 can be used for neurological disorder study[1][2].
CAS Number
26766-35-8
UNSPSC
12352005
Target
Cytochrome P450; Monoamine Oxidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ly43578.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(C1=CC=C(C=C1)Cl)(C2=CN=CN=C2)C3=CC=C(C=C3)Cl
Molecular Formula
C17H12Cl2N2O
Molecular Weight
331.20
References & Citations
[1]Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8 (4) :595-604.|[2]Gonzalez MI, et al. Injection of an aromatase inhibitor after the critical period of sexual differentiation. Pharmacol Biochem Behav. 1994;47 (1) :183-186.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
BA7276-10LY43578

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