Doramectin

CAT: 0804-HY-17035-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17035-01Size:100 mg
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Description
Doramectin is a derivative of Ivermectin (HY-15310) . Doramectin is a potent antiparasitic antibiotic. Doramectin is an active compound against S.mansoni in an NMRI mouse infection model[1][2][3].
CAS Number
[117704-25-3]
UNSPSC
12352005
Hazard Statement
H301, H410
Target
Antibiotic; Bacterial; Parasite
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Doramectin.html
Concentration
10mM
Purity
98.98
Solubility
DMSO : ≥ 50 mg/mL
Smiles
CO[C@@H]1[C@@H](O[C@]2([H])O[C@@H](C)[C@H](O)[C@@H](OC)C2)[C@H](C)O[C@@]([H])(O[C@H](/C(C)=C/C[C@]3([H])C[C@]([H])(OC4=O)C[C@]5(C=C[C@H](C)[C@@H](C6CCCCC6)O5)O3)[C@@H](C)/C=C/C=C7CO[C@@]8([H])[C@]\7(O)[C@@]4([H])C=C(C)[C@H]8O)C1
Molecular Formula
C50H74O14
Molecular Weight
899.11
Precautions
H301, H410
References & Citations
[1]Davey RB, Pound JM, Klavons JA, Lohmeyer KH, Freeman JM, Olafson PU. Analysis of doramectin in the serum of repeatedly treated pastured cattle used to predict the probability of cattle fever ticks (Acari: Ixodidae) feeding to repletion. Exp Appl Acarol. 2012 Apr;56 (4) :365-74. doi: 10.1007/s10493-012-9525-1.|[2]Wang XJ, Zhang J, Wang JD, Huang SX, Chen YH, Liu CX, Xiang WS. Four new doramectin congeners with acaricidal and insecticidal activity from Streptomyces avermitilis NEAU1069. Chem Biodivers. 2011 Nov;8 (11) :2117-25. doi: 10.1002/cbdv.201000295.|[3]Gordana Panic, et al. Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni. PLoS Negl Trop Dis. 2015 Jul 31;9 (7) :e0003962.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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