Cefotetan

• Description :

  Cefotetan is a binding agent that targets human Raf1 kinase inhibitor protein (hRKIP) . Cefotetan binds to hRKIP, reduces the binding space between hRKIP and Raf1 kinase, relieves hRKIP's inhibition of the Ras/Raf1/MEK/ERK signaling pathway, and enhances ERK phosphorylation. Cefotetan can be used to study diseases associated with dysregulated Ras/Raf1/MEK/ERK signaling pathways. Cefotetan is also a broad-spectrum antibacterial agent that disrupts cell wall synthesis by binding to bacterial penicillin-binding proteins (PBPs) . It is used to study bacterial infections such as bone, skin, urinary tract, and lower respiratory tract[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H317

• Target :

  Antibiotic; Bacterial; ERK; MEK; Raf; Ras

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/cefotetan.html

• Purity :

  99.75

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@](OC)(NC(C(S/4)SC4=C(C(O)=O)/C(N)=O)=O)C1=O)O

• Molecular Formula :

  C17H17N7O8S4

• Molecular Weight :

  575.62

• Precautions :

  H317

• References & Citations :

  [1]Guo C, et al. Cefotetan-bound human RKIP involves in Ras/Raf1/MEK/ERK signaling pathway. Acta Biochim Biophys Sin (Shanghai) . 2022 Dec 25;54 (12) :1917-1923.|[2]Phillips I, et al. Cefotetan: in-vitro antibacterial activity and susceptibility to beta-lactamases. J Antimicrob Chemother. 1983 Jan;11 Suppl:1-9.|[3]Komiya M. et al. Absorption, distribution, metabolism, and excretion of cefotetan (YM09330) in experimental animals[J]. Chemotherapy, 1982, 30 (Supplement1) : 106-118.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  β-lactam

• CAS Number :

  [69712-56-7]