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Cefotetan

CAT: 0804-HY-N6670-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6670-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cefotetan is a binding agent that targets human Raf1 kinase inhibitor protein (hRKIP) . Cefotetan binds to hRKIP, reduces the binding space between hRKIP and Raf1 kinase, relieves hRKIP's inhibition of the Ras/Raf1/MEK/ERK signaling pathway, and enhances ERK phosphorylation. Cefotetan can be used to study diseases associated with dysregulated Ras/Raf1/MEK/ERK signaling pathways. Cefotetan is also a broad-spectrum antibacterial agent that disrupts cell wall synthesis by binding to bacterial penicillin-binding proteins (PBPs) . It is used to study bacterial infections such as bone, skin, urinary tract, and lower respiratory tract[1][2][3].
CAS Number
69712-56-7
UNSPSC
12352005
Hazard Statement
H317
Target
Antibiotic; Bacterial; ERK; MEK; Raf; Ras
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cefotetan.html
Purity
99.75
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@](OC)(NC(C(S/4)SC4=C(C(O)=O)/C(N)=O)=O)C1=O)O
Molecular Formula
C17H17N7O8S4
Molecular Weight
575.62
Precautions
H317
References & Citations
[1]Guo C, et al. Cefotetan-bound human RKIP involves in Ras/Raf1/MEK/ERK signaling pathway. Acta Biochim Biophys Sin (Shanghai) . 2022 Dec 25;54 (12) :1917-1923.|[2]Phillips I, et al. Cefotetan: in-vitro antibacterial activity and susceptibility to beta-lactamases. J Antimicrob Chemother. 1983 Jan;11 Suppl:1-9.|[3]Komiya M. et al. Absorption, distribution, metabolism, and excretion of cefotetan (YM09330) in experimental animals[J]. Chemotherapy, 1982, 30 (Supplement1) : 106-118.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
β-lactam

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