15 (R) -PTA2

• Description :

  15 (R) -PTA2 (15 (R) -Pinanethromboxane A2) is an antithrombotic agent that inhibits platelet aggregation. 15 (R) -PTA2 inhibits stable prostaglandin endoperoxide analog-induced constriction of feline coronary arteries and stabilizes hepatic lysosomes. 15 (R) -PTA2 also inhibits thromboxane synthase but has no effect on prostacyclin synthase[1].

• Product Name Alternative :

  15 (R) -Pinanethromboxane A2

• UNSPSC :

  12352211

• Hazard Statement :

  H225-H319

• Target :

  Prostaglandin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/15-r-pta2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC(CCC/C=C\C[C@H]1[C@@]2([H])C(C)([C@](C[C@@H]1/C=C/[C@H](O)CCCCC)([H])C2)C)=O

• Molecular Formula :

  C24H40O3

• Molecular Weight :

  376.57

• Precautions :

  P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P370+P378-P403+P235-P501

• References & Citations :

  [1]Nicolaou KC, et al. Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation. Proc Natl Acad Sci U S A. 1979 Jun;76 (6) :2566-70.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [71154-83-1]